Anti-ACTIVE® Caspase-3 pAb Product Information

Literature # 9PIG748

Anti-ACTIVE® Caspase-3 pAb is intended for use as a marker of apoptosis; it specifically stains apoptotic human cells without staining nonapoptotic cells. Cysteine proteases called caspases are among the mediators of the execution phase of apoptosis. Caspase-3 is a central player in mediating apoptosis and is the most widely studied caspase. All known caspases are synthesized as proenzymes activated by proteolytic cleavage. Anti-ACTIVE® Caspase-3 pAb is an affinity-purified rabbit polyclonal antibody directed against a peptide from the p18 fragment of human caspase-3. The antibody is affinity purified using a peptide corresponding to the cleaved region of caspase-3.